Francisca B. M. Sousa | Isabela R. S. G. Nolêto | Leticia S. Chaves | Gabriella Pacheco | Ana P. Oliveira | Mikhail M. V. Fonseca | Jand V. R. Medeiros
Date of Publication:
Jul 31, 2020
The Journal of Pharmacy and Pharmacology
The oral rehydration solution is the most efficient method to treat cholera; however, it does not interfere in the action mechanism of the main virulence factor produced by Vibrio cholerae , the cholera toxin, and this disease still stands out as a problem for human health worldwide. This review aimed to describe therapeutic alternatives available in the literature, especially those related to the search for molecules acting upon the physiopathology of cholera.
Knowing therapeutic alternatives and their molecular mechanisms for the treatment of cholera could guide us to develop a new drug that could be used in combination with the rehydration solution.